Scientist, Cell Engineering

An affiliate of Colossal is hiring a Scientist that will derive non-model organism primary cell lines, conduct assays corresponding to cell health, characterize lines, perform transfections, and deliver edited lines for downstream SCNT. The candidate will be part of a core team responsible for optimizing and characterizing for lines derived in house and supporting other parts of the cell core team in gene editing workflows. This position reports to the Manager of Primary Cell and Production sub-team within the Cell Engineering and Production (CEP) core team.  This position is based out of Dallas, TX. Relocation assistance is available. Duties and Responsibilities: Isolate, expand, and maintain high-quality primary cell cultures from diverse non-model animal tissues. Innovate then execute experiments to generate and characterize primary cells from non-model mammalian organisms, develop functional assays, assess and interpret experimental workflows Work with team members to assess efficiency of workflows through cellular assays and NGS sequencing approaches Work closely with genome engineers to screen, validate, and make cell lines that will undergo SCNT Work on project milestones Attend lab meetings, prepare reports and presentations on the progress of projects Great organizational skills and excellent laboratory record maintenance Required Skills and Abilities: Expert knowledge of primary cell derivation, culture, propagation, and biobanking Expert knowledge and hands-on experience in CRISPR gene editing, including proficiency with multiple gene delivery methods such as chemical transfection, electroporation, and LNP delivery. Experience with flow cytometry, immunostaining, confocal microscopy Microdissection experience Strong Aseptic Technique and ability to work with antibiotic free culture Strong written and oral communication skills, as well as creative problem-solving skills Enjoys the fast-paced startup environment and teamwork Exceptional organizational skills, multitasking, and attention to detail. Strong emotional intelligence and passion for building relationships across all levels. Strong analytical and problem-solving skills. Ability to function well in a growth-oriented, nimble environment. Preferred Experience: Experience with automated cell culture workflows. Previous work with mESC editing pipelines Required Education and Experience: PhD in biological sciences, stem cell biology, genetics or related field. BS/MS with significant relevant experience will also be considered 4+ years hands-on expertise in mammalian cell culture systems What Colossal Offers Full-Time Employees: Medical, dental, and vision coverage Excellent paid time off and company holidays so you can rest and recharge  Flexible spending accounts (FSA) Company matched 401k retirement plan Paid parental leave at 100% salary for up to 12 weeks Education reimbursement  An opportunity to help us return the Earth to a healthier state The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.  Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal. Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.   EEO is the Law  Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.  Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026: #1 on the 50 Best Startups to Work For in Dallas in 2023! 100 Best Midsize Places to Work in Dallas in 2024 & 2025 100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026. Built In 2026 Award Lists Great Place to Work Certification Page Most Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals. Newsweek's Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!                     

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