Senior Scientist, Analytical Chemistry

About Us Deep Genomics is at the forefront of using artificial intelligence to transform drug discovery. Our proprietary AI platform decodes the complexity of RNA biology to identify novel drug targets, mechanisms, and therapeutics inaccessible through traditional methods. With expertise spanning machine learning, bioinformatics, data science, engineering, and drug development, our multidisciplinary team in Toronto and Cambridge, MA is revolutionizing how new medicines are created.

Opportunity This role based in Cambridge, MA is focused on the analytical characterization and formulation of oligonucleotides in support of the research efforts at Deep Genomics. The individual in this role will assure the identity and purity levels of oligonucleotides as they are obtained from external CROs as well as from pre-clinical in vitro and in vivo metabolism experiments. The person in this role will also be responsible for the formulation of oligonucleotides for in vitro and in vivo experimentation. Further, responsibility for the management of research samples falls within the remit of this role. The person in this role will also lead the strategy formulation and implementation of an internal build of oligonucleotide analytics lab at Deep Genomics.

Maintain efficient workflows for analytical characterization of DG oligos at CROs. Working with the leader of Molecular Design Chemistry, develop and implement a potential, future plan for the installation of an LCMS system for analysis of oligonucleotides. Act as DG KOL for characterization of oligonucleotides in terms of identify, purity, and stability. Develop analytical methods for the future LCMS system to characterize research oligonucleotide samples including characterization of chemical and metabolic stability. Generate Certificate of Analysis reports from such data. Perform formulation processes to provide research samples ready for in vitro and in vivo experimentation including endotoxin analysis. Develop and maintain a sample tracking system for the compounds that come into Deep Genomics at Cambridge. Future responsibilities may include bioanalysis of PK samples.

PhD in analytical, pharmaceutical sciences, or bio-organic chemistry including expertise in HPLC (high pressure liquid chromatography) and mass spectrometry with 2 years experience; MS in similar fields with +5 years experience. Excellent communication skills coupled with good collaboration style. Experience in the laboratory techniques for oligonucleotides. Experience in designing and implementing new processes for oligonucleotide samples.

Experience with oligonucleotide therapeutics, analytics, and formulation. Understanding of in vitro assays and/or in vivo experiment involved in ADAR, siRNA and ASO-modality therapeutics. Experience in bioanalysis and GxP methods and laboratory operations would be a benefit.

A collaborative and innovative environment at the frontier of computational biology, machine learning, and drug discovery. Highly competitive compensation, including meaningful stock ownership. Comprehensive benefits - including health, vision, and dental coverage for employees and families, employee and family assistance program. Flexible work environment - including flexible hours, extended long weekends, holiday shutdown, unlimited personal days. Maternity and parental leave top-up coverage, as well as new parent paid time off. Focus on learning and growth for all employees - learning and development budget & lunch and learns. Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development, and in Kendall Square, Cambridge, Mass. - a global center of biotechnology and life sciences.

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