Senior Scientist I Analytical Development

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.  The   small   molecule   CMC   team   is   seeking   highly   motivated   Sr.  Scientist   I  of   Analytical   Dev e lopment   to   help   build   our   dynamic   small   molecule CMC   group   at   Alumis .  The successful candidate will help to  support  the   analytical development  and quality control  activities  from the  preclinical  phase through late-stage clinical development. Having  analytical development   expertise  and experience in working with CMOs/CTLs,  coupled with  thorough   understanding of the associated quality  and regulatory  awareness are key assets.   RESPONSIBILITIES   Support  development, validation ,  and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs     Execute  and/or  support the in-house method development  activities  using  UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and technique s   for Phase 1 to late-stage drug development   Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports     Trend  stability and release data using statistical methods   Assist  in investigation for various non-conformance events at CMOs/CTLs   Collaborate with  CMC team,  QA and CMOs /CTLs  towards  timely  generation and approval of documents   Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams   Author  technical reports and documents in support of regulatory filing   Assist  in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)   THE IDEAL  CANDIDATE   BS/ MS   in   chemistry   or pharmaceutical sciences  with   5 +   years   of   experience   in   analytical development   Experience with analytical techniques for small drug molecules and oral solid formulations  required , including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques   Proven  track record  in applying analytical techniques to solve challenging problems   Experience in working with CMOs and CTLs   Experience in early to late-stage drug development   Strong organizational and communication skills   Comfortable in a fast-paced small company environment and  a  strong team  player   Experience and  k nowledge  in  ICH,  cGMP  and regulatory requirements     This position is located in South San Francisco, CA. We are not considering fully remote applicants. The salary range for this position is $112,000 USD to $135,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.   Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus & Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to  elevate ,  challenge  and  nurture one another along the way. Alumis Inc. is an equal opportunity employer.

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