Senior Scientist (Supervisor) #4874

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Senior Scientist is a scientific and people supervisor responsible for driving platform troubleshooting and assay development while building, leading, and developing a high-performing team of scientists and research associates. This role provides scientific and technical supervision, oversees execution of research activities, establishes team priorities, mentors and develops talent, and collaborates cross-functionally to ensure reliable platform operation and continuous innovation. This position works on-site full-time, 5 days/week at our office located in Durham, NC

Independently design, plan, and execute experiments to support platform troubleshooting, optimization, and other research objectives. Analyze, interpret, and present experimental results to identify root causes of platform performance issues and provide scientifically sound recommendations. Develop, optimize, and troubleshoot experimental methods, protocols, and workflows to improve platform performance, robustness, efficiency, and data quality. Investigate technical challenges, identify sources of variability, and implement corrective actions to ensure reliable platform operation. Provide day-to-day supervision, coaching, performance feedback, and career development for direct reports. Establish team priorities, allocate resources, and ensure timely execution of project deliverables. Prepare detailed technical reports, presentations, and documentation summarizing troubleshooting investigations, platform performance, and research findings. Collaborate with cross-functional teams to resolve platform-related issues and integrate findings into broader research and development strategies. Ensure compliance with laboratory safety, quality, and regulatory standards while maintaining platform reliability and operational excellence.

PhD in Molecular Biology, Biochemistry, Biotechnology, or related scientific discipline with 2-5 years of relevant research or industry experience; OR Master’s degree with 5-8 years of relevant experience; OR Bachelor’s degree with 8+ years of relevant experience. Demonstrated expertise in molecular biology, protein chemistry, or related experimental approaches. Proven experience in independently designing and executing experiments from concept to data interpretation. Strong track record of technical contributions in research, as evidenced by publications, presentations, or project outcomes. Proficiency with relevant laboratory techniques and data analysis tools. Effective written and verbal communication skills for technical reports, publications, and presentations. Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include: GMP quality management systems (e.g. ISO 13485) Clinical laboratory regulations (e.g. CAP, CLIA, NYSDOH, ISO 15189) Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)

Advanced technical and analytical skills with the ability to troubleshoot complex scientific problems. Strong organizational and project management abilities, including the capacity to prioritize multiple projects. Ability to lead and mentor less-experienced team members. Collaborative mindset with the ability to work effectively in cross-functional research environments. Innovative thinker with the ability to contribute to the development of new technologies and approaches.

Work will be performed in an office environment and in a laboratory setting with exposure to biological samples, chemicals, and laboratory equipment. Requires consistent use of personal protective equipment (PPE), including lab coats, gloves, and safety glasses. May involve extended hours to meet deadlines or conduct time-sensitive experiments. Physical requirements include standing for extended periods, pipetting, and handling laboratory equipment and samples.

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