(Senior) Scientist, Translational Biology

Company Summary FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact. Position Summary We are seeking a highly motivated and experienced Scientist to join our research team. The ideal candidate will have deep expertise in flow cytometry, primary cell isolation and sorting, microscopy and imaging, and gene-silencing techniques (siRNA), with in vivo/in vitro mouse experience. This role will contribute to the design and execution of preclinical studies to advance therapeutic programs. Key Responsibilities Design, execute, and analyze complex in vitro / in vivo experiments to support research programs Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation Perform and optimize primary cell isolation from tissues, including enzymatic and mechanical tissue dissociation, magnetic-activated cell sorting (MACS), and fluorescence-activated cell sorting (FACS), with attention to preserving cell viability, yield, native gene-expression signatures, and potential for further culture of the cells Perform and interpret microscopy-based assays, including high-content microscopy, immunofluorescence, confocal, and/or intravital imaging, to characterize cell and tissue phenotypes and validate target engagement Support mouse studies as needed, including disease models, dosing, tissue collection, and phenotypic analysis Develop and apply siRNA-based approaches for target validation and mechanistic studies Analyze and interpret data, generate reports, and present findings to cross-functional teams Collaborate with internal and external stakeholders to advance project goals Mentor junior scientists and contribute to a collaborative team environment Maintain accurate experimental records and ensure compliance with institutional and regulatory guidelines Qualifications Ph.D. in Molecular Biology, Cell Biology, or a related field with 3–6+ years of relevant experience (industry preferred), or M.S. with significant experience Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis (e.g., FlowJo or similar tools) Hands-on experience with primary cell isolation techniques from mouse tissue, including tissue dissociation (enzymatic and mechanical), magnetic bead-based separation (MACS), and isolation of rare or fragile cell populations Hands-on experience with microscopy techniques (e.g., immunofluorescence, confocal microscopy) and associated image analysis software (e.g., ImageJ/Fiji, Imaris, or similar) Demonstrated experience with siRNA design, delivery, and functional validation Strong data analysis and problem-solving skills Excellent communication and presentation skills Ability to work independently and collaboratively in a fast-paced environment Preferred Qualifications Experience with mouse models, including in vivo study design, dosing, and tissue collection Experience in translational or preclinical research environments Experience with cold-active or optimized dissociation protocols for isolating sensitive/rare cell types (e.g., podocytes, neurons, microglia) while minimizing dissociation-induced expression artifacts Experience with advanced imaging modalities (e.g., intravital microscopy, super-resolution, high-content imaging) Familiarity with additional molecular techniques (qPCR, Western blot, ELISA, RNA-seq, gene silencing, protein over-expression) Experience working in a biotech or pharmaceutical setting About Flagship Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at  www.flagshippioneering.com . Flagship Pioneering is committed to  equal employment opportunity  regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. Privacy Notice for Applicants:  When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.  The salary range for this role is $126,000 - $165,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL106 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL106's good faith estimate as of the date of publication and may be modified in the future.   Privacy Notice for Applicants:  When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com. 

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