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Full Job Description

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Your mission

We are seeking a highly innovative and experienced Bioanalytical Lead to bridge the gap between our predictive AI design platform and wet-lab preclinical execution.

In this role, you will define the overarching bioanalytical strategy across our expanding portfolio, covering small molecules, advanced biologic formats, and Antibody-Drug Conjugates (ADCs) in both non-GLP and GLP environments. You will collaborate closely with the drug design teams, design robust bioanalytical assays, manage global Contract Research Organizations (CROs), and lead the logistical execution required to rapidly advance our candidates toward IND submission.

As the Bioanalytical Lead, you will serve as the technical expert for our diverse portfolio of computationally designed therapeutic candidates. As part of the preclinical development function, this is a high-impact leadership role responsible for building the bridge between Isomorphic’s AI-driven discovery engine and the effective execution of our robust preclinical strategies, alongside safety and DMPK. The successful candidate will be forward thinking, thrive in fast-paced, agile environment and ready to embrace Iso’s AI-first mindset and challenge the status quo. With a broad range of internal and external stakeholders, candidates will be expected to have exceptional communication and influencing skills.

Bioanalytical Strategy & AI Integration

• Define and execute comprehensive bioanalytical strategies for small molecules, large molecules, and complex modalities (ADCs) from discovery through preclinical development covering both non-GLP and GLP environments.

• Oversee the design, validation, and transfer of robust PK, PD, and immunogenicity (ADA) assays at external labs.

• Collaborate with AI/machine learning scientists to integrate bioanalytical data back into predictive models, helping to continuously improve our platform's accuracy.

• Lead biomarker assay strategies, utilizing both traditional approaches and AI-identified novel biomarkers to support preclinical proof-of-concept.

Global CRO Management & Logistics

• Select, qualify, and manage a high-performing network of global CRO partners, ensuring rigorous data quality, strict timelines, and budget alignment.

• Master complex global logistics, including international sample shipments, cold-chain management, import/export compliance, and stability tracking across borders to ensure data integrity.

• Serve as the primary technical point of contact for CROs, troubleshooting complex assay anomalies rapidly.

Cross-Functional Leadership and Regulatory Authoring

• Work seamlessly at the intersection of Drug Discovery, Translational Medicine, and Computational Biology to drive candidates into the clinic.

• Author and review high-quality regulatory documents, specifically bioanalytical sections of Investigational New Drug (IND) applications and Investigator Brochures (IBs).

• Represent the bioanalytical function in cross-functional project teams and during interactions with regulatory agencies (FDA, EMA, etc.).

Required expertise and experience

• Ph.D. in Biochemistry, Analytical Chemistry, Pharmacology, or a related scientific discipline with 5+ years of biotech/pharmaceutical industry experience; OR a B.S./M.S. with 8+ years of equivalent experience.

• Proven track record of leading bioanalytical strategies across multiple modalities (must include small molecules, biologics, and ADCs).

• Deep understanding of GLP and non-GLP preclinical study regulations, FDA/EMA bioanalytical method validation guidelines, and ICH guidelines.

• Technical & Logistical Expertise

• Extensive experience with diverse analytical platforms (e.g., LC-MS/MS, LBA, flow cytometry).

• Demonstrated success in biomarker assay development and validation.

• Expert knowledge of global sample shipping logistics, biosafety regulations, and maintaining chain-of-custody for precious preclinical samples.

• Experience writing bioanalytical sections for successful IND submissions.

Nice to have

• Experience of generating reagent in collaboration with drug design teams

• Experience of developing or using AI tools (LLM) to accelerate processes including reporting

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

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